Open access
Sep 2026
Cardiomyocyte-specific loss of Smyd5 leads to a robust activation of inflammatory signaling and heart failure in mice
It is demonstrated that loss of Smyd5 induces rapid progression to heart failure accompanied by robust inflammatory activation, including a ∼100-fold increase in Il-6 expression, accompanied by rapid progression of cardiac remodeling and heart failure.
R. Bia, Samuel M. Hickenlooper, Mickey R. Miller et al.
· bioRxiv · 0 citations