Author

Kong-Peng Lam

2 papers indexed here

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Review Open access Sep 2026

IL-10’s contextual role in cytotoxic antitumor immunity: evidence, controversies, and therapeutic translation

Interleukin-10 (IL-10) is classically defined as a potent anti-inflammatory cytokine that protects tissues by constraining myeloid activation and limiting inflammatory cytokine production. Yet, accumulating evidence indicates that, in defined contexts, IL-10 can also promote antitumor immunity by enhancing the fitness...

Min-Chuan Zhang, Qi-Jing Li, Kong-Peng Lam et al. · Frontiers in Immunology · 0 citations

Open access Jul 2026

G3BP1 methylation by PRMT5 facilitates its recruitment of TBK1 for IRF3 activation during host response to foreign ribonucleic acids

Background and aim Ras GTPase-activating protein SH3 domain-binding protein 1 (G3BP1) has been shown to bind cytosolic nucleic acid sensors including retinoic acid-inducible gene I (RIG-I) and cyclic GMP-AMP synthase (cGAS) in innate immunity. As a scaffolding protein enhancing protein-protein and protein-RNA interacti...

Wen Song, Susana Soo-Yeon Kim, Candice Yam et al. · Frontiers in Immunology · 0 citations