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Author

Klaus H. Kaestner

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2 papers indexed here

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Open access Oct 2026

The ortholog of the Human T2D Risk Gene STEAP2 is Required for Glucose Stimulated Insulin Secretion in Mice

Type 2 diabetes is a complex metabolic disease with a strong genetic component, yet this genetic risk is driven by common variants in up to 600 loci with small effect sizes. Variants in the STEAP2 locus, encoding ‘Six-transmembrane epithelial antigen of the prostate-2’, are highly associated with altered glycemic trait...

Avery Hawthorne, Kai Kelly, Mark Tigue et al. · 0 citations
Open access Jul 2026

Modeling immune responses to autologous and allogeneic human stem cell-derived islet grafts in vivo 2332710

While allogeneic grafts undergo strong immune infiltration and tissue remodeling, autologous stem cell-derived islet grafts remain largely protected, even in the presence of autoreactive T cells, indicating that additional stimuli may be required to trigger autoimmune β-cell targeting in vivo.

Giorgia Zanetti, Camillo Bechi Genzano, Sakshi Bhatele et al. · 0 citations

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