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Author

Kirill Petriukov

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Open access Sep 2026

Trans-branching of polyubiquitin chains orchestrates the DNA replication stress response

This study identifies hyper-accumulation of daughter-strand gaps as the mechanistic basis underlying the toxicity of inhibitors of the PCNA-specific isopeptidase, USP1, in BRCA1-deficient cells.

Kirill Petriukov, Christian Renz, Markus S. Schraft et al. · 0 citations

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