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Author

Kingshuk Ghosh

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#machine learning Preprint Sep 2026

MT-ProtBERT: Multi-task Learning ProtBERT for Intrinsically Disordered Proteins Classification with Scarce Data

MT-ProtBERT consistently outperforms PARROT, an RNN-based IDP-specific model, across all tasks, and demonstrates that combining self-supervised and biochemistry-informed tasks, and multi-scale learning enables robust modeling of unstructured proteins under data scarcity.

Jian Sun, Kingshuk Ghosh, Lilianna Houston et al. · 0 citations
#protein folding Sep 2026

Conformational Landscape of a Marginally Disordered Protein HYPK and its Charge-Variant Mutant in the Context of Folded Domains

Intrinsically disordered proteins (IDPs) can have varying proportions of disordered and structured regions, and various fractions of amino acids promoting these regions. This raises the possibility that some IDPs may behave as marginal proteins, exhibiting properties of both disordered and folded states. HYPK is one...

Kari Gaalswyk, M. Gruebele, Kingshuk Ghosh · 0 citations

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