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Author

Kimberley J. Evason

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2 papers indexed here

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Open access Sep 2026

Multi-Modal Kinome Profiling Discovers Mesenchymal-Like Polarity Networks that Underly Directed Hepatocellular Carcinoma Cell Migration

Metastasis and associated therapy resistance remain the principal drivers of cancer related death, and there is a pressing need for a deeper mechanistic understanding and anti-metastatic therapies. For patients that suffer from hepatocellular carcinomas (HCCs), which are the most common primary liver cancers, frequent...

T. A. Rants'o, Kathryn Woods, Paige Jensen et al. · 0 citations
Open access Sep 2026

Excessive EFHD1-dependent ER-mitochondrial contacts drive a maladaptive antiviral response in metabolic liver disease

It is shown that EFHD1, a Ca2+-dependent actin cross-linker, stabilizes endoplasmic reticulum–mitochondria contact sites (ERMCS) by detecting spatiotemporal coincidence of interorganellar proximity and ER Ca2+ release, and suggested EFHD1 inhibition as a therapeutic strategy.

D. Eberhardt, Emma C. Rekate, Yasmin B. Masini et al. · 0 citations

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