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Author

Kieran F. Harvey

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Open access Aug 2026

The mechanosensitive protein Zyxin influences Hippo signaling and tissue growth via adherens junctions and basal spot junctions in Drosophila.

Mechanical forces such as tension and compression play a central role in the growth and morphogenesis of tissues. Cell-cell junctions and the actin cytoskeleton are key mediators of mechanical forces and influence the activity of signaling networks, including the Hippo pathway. Here, we show that the mechanosensitive p...

Harmanjeet Singh, Elliot Brooks, Connor Keegan et al. · 1 citation
Jul 2026

SUMOylation enhances DNMT1 function to repress mega-intergenic RNAs and viral mimicry

It is shown that DNMT1 is enriched at unmethylated CpG islands of actively transcribed genes largely by its CXXC domain, and RFN4-mediated SUMOylation enhances DNMT1 mobility and DNA methylation, thereby promoting the suppression of endogenous retroviral element-dependent viral mimicry.

Brian J. Liddicoat, Jesse J. Balic, W. Jia et al. · 1 citation

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