Author

kian-Haut Lim

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Clinical trial Open access Sep 2026

Synthetic long peptide and DNA personalized cancer vaccines induce robust neoantigen-specific T cell responses in pancreatic cancer

Pancreatic ductal adenocarcinoma (PDAC) is unresponsive to standard immunotherapies despite harboring cancer neoantigens capable of eliciting T cell responses. We completed two phase 1 clinical trials (NCT03956056 and NCT03122106) evaluating safety and immunogenicity of synthetic long peptide (SLP) and DNA personalized...

Felicia Zhang Perkins, Xiu-Li Zhang, Y. Yu et al. · Science Advances · 0 citations

Sep 2026

Abstract B099: Tumor progression locus 2 kinase drives pancreatic cancer immune evasion through a MYBL2-CXCL10 signaling axis

Pancreatic ductal adenocarcinoma (PDAC) is characterized by a chronically inflamed tumor microenvironment (TME) driven by persistent activation of innate inflammatory signaling. Tumor progression locus 2 (TPL2; MAP3K8) is a serine/threonine kinase downstream of KRAS that activates both MAPK and NF-κB signaling; howev...

Hua-Ping Li, Yu-Tong Geng, Hung-Han Huang et al. · Cancer Research · 0 citations