Open access
Jul 2026
Tumor-derived annexin A1 drives lenvatinib resistance by regulating SOX2/STAT3/S100A6 feedback loop and M2 macrophage polarization in hepatocellular carcinoma
The critical role of HCC-derived ANXA1 regulates lenvatinib resistance both intrinsically and extrinsically is demonstrated, and Targeting the SOX2/ANXA1/STAT3/S100A6 positive loop may provide a novel therapeutic strategy for HCC treatment.
Catherine Yu Jia Gu, C. Leung, R. Leung et al.
· Cell Death & Disease · 0 citations