Khyati Dalal

Cooperativity enables widespread role of low-affinity motifs in chromatin accessibility and increases regulatory potential.

Low-affinity transcription-factor (TF) motifs are an important element of the cis-regulatory code, yet they are notoriously difficult to map and mechanistically incompletely understood, limiting our ability to interpret non-coding variation in development, evolution, and disease. Here, we investigate their role in pion...