Targeted Intranasal Delivery of Antiretrovirals for NeuroAIDS: Opportunities, Barriers, and Formulation Strategies
NeuroAIDS refers to the spectrum of neuropsychiatric complications observed in approximately 30–50% of HIV/AIDS patients. Although the advent of antiretroviral therapy has reduced the severity of AIDS, mild cognitive deficits persist in nearly half of treated patients, highlighting limitations in central nervous system...