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Author

Kevin Van Bortle

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Review Open access Oct 2026

The NuRD complex shapes RNA polymerase III activity at highly expressed tRNA gene clusters, tuning the dynamic range of cellular tRNA pools.

RNA polymerase III (Pol III) transcription produces RNAs involved in core biological processes and is therefore coupled to fluctuating demands for protein synthesis and cell growth. However, the mechanisms underlying dynamic Pol III regulation remain incompletely understood. To address this gap, we investigated protein...

Rui-Ying Cheng, Rajendra K. C., Simon Lizarazo et al. · 2 citations
Open access Sep 2026

ATF4 Modulates Group 1 mGluR-Dependent molecular signaling, hippocampal plasticity and behavior.

Group 1 metabotropic glutamate receptors (Gp1 mGluRs) are critical effectors in behavior. Abnormal Gp1 mGluR signaling is frequently observed in neurodevelopmental and cognitive disorders. It is established that activation of Gp1 mGluR elicits translation-dependent neuronal plasticity mechanisms, such as long-term syna...

Shi-Yu Wang, Yeeun Yook, Simon Lizarazo et al. · 0 citations

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