Author

Kevin Pethe

2 papers indexed here

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Open access Aug 2026

Growth-dependent tRNA reprogramming and codon bias link translation to metabolic state in Enterococcus faecalis

ABSTRACT Enterococcus faecalis is a gram-positive commensal bacterium of the human gut microbiome and an opportunistic pathogen responsible for many hospital-acquired infections. Despite the clinical importance of E. faecalis, how gene and protein expression are coordinated with growth remains poorly defined. Here, we...

M. M. Mitchener, Caleb M. Anderson, Mark Veleba et al. · mBio · 0 citations

Open access Sep 2026

Inhibition of type II NADH dehydrogenase in Mycobacterium tuberculosis reveals collateral vulnerability in the electron transport chain

ABSTRACT To sustain the anti-tuberculosis drug development pipeline, novel antibiotics must be developed both as standalone agents and as components of future combination regimens. To this end, tricyclic-spirolactams (TriSLa)-based inhibitors of mycobacterial type II NADH dehydrogenase (Ndh-2) represent a promising nov...

Vien Q. T. Ho, Vincent Fontaine, Ernesto Anoz-Carbonell et al. · Antimicrobial Agents and Che... · 0 citations