Open access
Aug 2026
A protein–foldamer supramolecular synthon for self-assembled hybrid architectures
Constructing artificial assemblies that combine proteins and synthetic ligands has been hampered by the lack of protein–ligand interfaces that are sufficiently large and organized to enable precise structural control. Here ribosome display selection is used to identify a protein that binds a helical aromatic foldamer b...
Johannes Sigl, Vasily Morozov, Ling-Fei Wang et al.
· Nature Chemistry · 1 citation