Diastereoselective Synthesis of Tetrahydroquinolines through a Multi-component Aza-Prins-Ritter Reaction Sequence.
A series of substituted tetrahydroquinoline (THQ) derivatives were synthesized via a triflic acid-promoted multicomponent aza-Prins-Ritter reaction of 2-(tosylamino)styrenes with carbonyl compounds and substituted acetonitriles, the latter serving as both solvent and nucleophile. The reaction proceeds under mild condit...