Keshuo Luo

Decoupling of allele frequency and predicted pathogenicity in the tandem repeat filaggrin (FLG) gene

Tandemly repetitive genes present a paradox in that their duplicated architecture may buffer against mutation yet often exhibits strong position-dependent functional constraints. The filaggrin gene ( FLG ), with its massive repetitive core, provides a key model to examine how repeat architecture and demographic f...