Author

Kenny Triplett

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Open access Aug 2026

Neuronal Ddit4 overexpression in the medial prefrontal cortex reduces synaptic density and impairs cognitive function in mice.

It is demonstrated that Ddit4 overexpression specifically in neurons is sufficient to reduce spine density in the PFC, impair temporal order memory, and induce transcriptional changes associated with stress and depression.

Alexander M. Kuhn, Kelly E. Bosis, Madeline M Mairose et al. · eNeuro · 0 citations