The Department of Physiology Scientific Retreat 2026
Th September, Carolyn Amaradio, Jonas Cook et al.
· 0 citations
3 papers indexed here
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Open access
Aug 2026
Single-Nucleus RNA-Seq of Human and Rat Cardiomyocytes Identifies Shared and Distinct Regulators and Features of Aging and Disease.
Age is the greatest risk factor for cardiovascular diseases, including heart failure (HF), which is a leading cause of morbidity and mortality. While left ventricular fibrosis, hypertrophy and decreased contractility are associated with cardiac aging, age is not sufficient for HF development. Despite diminished cardiom...
Samaneh Ekhteraei-Tousi, Rosa Doñate Puertas, M. Youness et al.
· Aging and Disease · 0 citations
Open access
Sep 2026
Mechano-sensing channels PIEZO1 and PIEZO2 regulate mitral valve serotonin-mediated homeostasis and pathophysiology.
A novel link between mechano-transduction, 5-HT production and receptor signaling, and collagen synthesis is identified, suggesting PIEZO1, PIEZO2, and downstream 5-HT pathways as potential therapeutic targets for mitigating MR progression.
Stanley J. Stachelek, Emily J. Hauber, Xiao-Qiu Yang et al.
· Cardiovascular Research · 0 citations