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Author

Kenia de los Santos-Alexis

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Open access Aug 2026

A novel CAF population coordinates hyper-suppressive regulatory T cell recruitment and localization in lung cancer

Across many solid tumor types, cancer-associated fibroblasts (CAFs) are abundant and heterogeneous, with distinct subpopulations exerting immunomodulatory functions. Here we identify a novel population of immunomodulatory CAFs (imCAFs) in primary lung adenocarcinoma and pulmonary metastases, characterized by cell adhes...

Olivia R. Ringham, Monica Rivera, Lucas F. Loffredo et al. · 1 citation
Open access Sep 2026

Engineered probiotics for tumor-targeted combination chemoimmunotherapy

The approach integrates enzyme/prodrug therapy and immunotherapy into a single bacterial delivery system, overcoming key limitations of conventional therapies by providing a rationally designed framework for spatially controlled chemoimmunotherapy.

Zao-Feng Yang, Jong-Seong Im, Noah Chen et al. · 0 citations

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