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Author

Kengo Sato

2 papers indexed here

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Open access Aug 2026

UTR-Diffusion: Conditional Diffusion Modeling for Multi-objective and Constrained UTR Design

Motivation The 5′ untranslated region (UTR) and the start-codon-proximal region of the coding sequence (CDS) jointly influence translation efficiency and local RNA secondary-structure stability, while synonymous codon choices throughout the CDS shape codon adaptation. Because the encoded protein is often predetermined,...

Chuan-Kai Dai, Kengo Sato · 0 citations
Open access Sep 2026

Conditional Generation and Inpainting of Non-Coding RNA Sequences with Masked Discrete Diffusion

Designing functional non-coding RNA (ncRNA) is fundamental to synthetic biology and RNA therapeutics, yet generative modelling for ncRNA has received far less attention than protein design. We present RNA-MDLM, a framework that extends Masked Discrete Language Models (MDLM) to the conditional generation and inpainting...

Utkarsh Upadhyay, Chuan-Kai Dai, Julian Herold et al. · 0 citations

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