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#protein folding Open access Oct 2026

BindRelay refines de novo binder designs while preserving binding modes

De novo protein design now enables the creation of high-affinity binders from a target structure alone. However, current design methods face a trade-off between site control and success rate. Generative models such as RFdiffusion and BoltzGen place binders at chosen sites but often require large candidate pools. Halluc...

Ken Osumi · 0 citations
#protein folding Open access Oct 2026

BindRelay refines de novo binder designs while preserving binding modes

De novo protein design now enables the creation of high-affinity binders from a target structure alone. However, current design methods face a trade-off between site control and success rate. Generative models such as RFdiffusion and BoltzGen place binders at chosen sites but often require large candidate pools. Halluc...

Ken Osumi · 0 citations
#protein folding Open access Oct 2026

ArcRefine improves de novo binder designs while preserving binding modes

De novo protein design now enables the creation of high-affinity binders from a target structure alone. However, current design methods face a trade-off between site control and success rate. Generative models such as RFdiffusion and BoltzGen place binders at chosen sites but often require large candidate pools. Halluc...

Ken Osumi · 0 citations
#protein folding Open access Oct 2026

Structural carryover improves de novo binders while preserving binding modes

De novo protein design now enables the creation of high-affinity binders from a target structure alone. However, current design methods face a trade-off between site control and success rate. Generative models such as RFdiffusion and BoltzGen place binders at chosen sites but often require large candidate pools. Halluc...

Ken Osumi · 0 citations
#protein folding Open access Oct 2026

Structural carryover improves de novo binders while preserving binding modes

De novo protein design now enables the creation of high-affinity binders from a target structure alone. However, current design methods face a trade-off between site control and success rate. Generative models such as RFdiffusion and BoltzGen place binders at chosen sites but often require large candidate pools. Halluc...

Ken Osumi · 0 citations

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