Abstract B094: CDK12 inhibition activates cGAS-STING-mediated antitumor immunity and enhances immune checkpoint blockade in basal-like PDAC
Pancreatic ductal adenocarcinoma (PDAC) remains a highly lethal malignancy with limited effective therapies. Using a patient-derived organoid-based drug screen, we identified cyclin-dependent kinase 12 (CDK12) as a promising therapeutic target, particularly in basal-like PDAC. CDK12 is a transcription-associated cycl...