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Open access Sep 2026

Tailoring lipid nanoparticles for application-specific mRNA delivery.

This study proposes an application-oriented re-engineering strategy that leverages the clinically validated SM-102 platform, enabling rational LNP optimization for diverse mRNA delivery and therapeutic scenarios and recommends SM-102/DSPC and SM-102/DOPE LNPs as preferred formulations for RAW 264.7 macrophages and IGRO...

Xin-Xin Yan, Li-Xin Lin, Yi-Fan Zhang et al. · 0 citations
Jul 2026

Decoding the Functional Roles of Individual Components in mRNA Lipid Nanoparticles.

This study comprehensively demonstrates the important roles of each lipid component in determining the in vivo fate of LNPs, guiding the rational design of next-generation LNP-based mRNA delivery systems.

Ke-Xin Su, Zichuan Wang, Lu Shi et al. · 1 citation

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