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Author

Ke-Xian Li

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Oct 2026

Usp3 negatively regulates Mda5-mediated antiviral response by attenuating its K63-linked ubiquitination in black carp.

Melanoma differentiation-associated gene 5 (MDA5) is a critical cytosolic RNA sensor that initiates type I interferon (IFN) signaling upon viral infection, and its activity must be tightly regulated to maintain immune homeostasis. Ubiquitin-specific protease 3 (USP3) has been identified as a negative regulator of RLR-m...

Wei Qin, Li-Xia Xie, Hui-Xian Shi et al. · 0 citations

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