Alnustone ameliorates atopic dermatitis by rebalancing TAp63/ΔNp63 to upregulate filaggrin and restore skin barrier function.
Atopic dermatitis (AD) is a chronic, pruritic, erythematous skin condition with skin barrier dysfunction, driven largely by filaggrin (FLG) deficiency; however, direct FLG-targeting therapeutics remains lacking. To identify novel natural products capable of enhancing FLG expression, we screened an in-house natural prod...