Immune checkpoint blockade has changed the management of several digestive system cancers, but its impact is highly context dependent. This review evaluates evidence for esophageal, gastric and gastroesophageal junction, colorectal, hepatocellular, biliary tract and gallbladder, and pancreatic cancers. Randomized phase...
Ke-Ran Sun, Hong-Ru Li, Hao Chi et al.· Biomedicines· 0 citations
Sepsis is a life-threatening condition with high mortality, in which sepsis-induced immunosuppression—characterized by CD4+ T cell dysfunction and apoptosis—worsens clinical outcomes. The mechanistic link between neutrophil extracellular traps (NETs) and CD4+ T cell fate in sepsis remains poorly elucidated. We integrat...
Hong-Ru Li, Xuan Wang, Ke-Ran Sun et al.· Molecular Medicine· 0 citations
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