Aug 2026
Mechanistic Characterization of GedF Reveals a Ser-Tyr Catalytic Core with a Flexible Basic Residue in a Filamentous Fungal Anthraquinone SDR.
The cleavage of the C10-C4a bond in anthraquinones is a key step in generating ring-opened quinone derivatives in filamentous fungi. GedF, a short-chain dehydrogenase/reductase (SDR) from Aspergillus terreus, together with the dioxygenase GedK, mediates this transformation, yet the enzymatic mechanism of GedF remains u...
Ning Xu, Yongsong Wu, Dan Liu et al.
· Biochemistry · 0 citations