Oct 2026
PTK7 scaffolds DNA-PKcs to promote DNA damage response and immune evasion in triple-negative breast cancer.
Xue-Ying Liu, Ke-Jing Zhang, Yu Zhang et al.
· Oncogene · 0 citations
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Oct 2026
MINDY1 drives metabolic-immune crosstalk via OGT-UGP2-UDPG axis to promote immunosuppressive macrophage reprogramming.
The efficacy of immune checkpoint blockade is limited in hepatocellular carcinoma (HCC) due to tumor-intrinsic mechanisms. Here we identify the deubiquitinase MINDY1 as a central regulator of metabolic-immune crosstalk that drives immunotherapy resistance in HCC. MINDY1 is significantly upregulated in immunotherapy non...
Ke-Jing Zhang, Kui Chen, Xing-Yu Mi et al.
· Metabolism: Clinical and Exp... · 0 citations