A 4-Arm polyethylene-glycol-based multivalent galactoside disrupts Pseudomonas aeruginosa biofilm and restores antibiotic susceptibility.
Results indicate that 4-Arm-PEG-Gal significantly disrupts mature biofilm and is specifically recognized by the lectin LecA, and compared to the use of antibiotics alone, the combination of 4-Arm-PEG-Gal and TOB reduces antibiotic usage by 75% and additionally eradicates 73% of the bacteria within the biofilm.