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Author

Ke-Dao Lai

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Oct 2026

A new isoflavone isolated from Brachypterum eriocarpum (F.C.How) Adema and Sirich. and its hypolipidemic activity.

Compound 1 dose-dependently reduced HMGCR protein levels, suggesting that the lipid-lowering activity in FFA-treated HepG2 cells is associated with HMGCR inhibition in the mevalonate pathway, though further in vivo studies are needed to validate the underlying mechanism.

Hong-Cun Liu, Xiao-Qing Tan, Jia-Hui Sun et al. · 0 citations
Review Sep 2026

Targeting depression: Pharmacological mechanisms and therapeutic targets.

This review provides a systematic and critical evaluation of pharmacological mechanisms in depression and related therapeutic targets and proposes future directions for antidepressant drug development, including novel target discovery, rational multi-target design, and optimization of preclinical-to-clinical translatio...

Hui-Qin Wang, Shi-Fen Dong, Suo Liu et al. · 0 citations

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