Hepatocyte RIPK1 scaffolding function protects against alcohol-induced liver injury by restraining ER stress-driven apoptosis and inflammation
Alcoholic liver disease (ALD) is a global health burden with limited therapeutic options. The pathogenesis of ALD involves hepatocyte death and inflammation, but the key regulatory mechanisms remain incompletely defined. Receptor-interacting protein kinase 1 (RIPK1) is a critical signaling molecule with distinct ki...