BACKGROUND
Hypertrophic cardiomyopathy (HCM) is a heritable trait with marked variability in expression and outcomes. Our aims were to discover new genetic loci associated with HCM and to test the effect of a new polygenic risk score (PRS) on incidence, phenotype and outcomes stratified by genotype status.
METHODS
A...
Luis R. Lopes, Nay Aung, S. van Duijvenboden et al.· Journal of Medical Genetics· 0 citations
This work identifies proteins that are potentially therapeutic targets for respiratory disease, and which warrant follow-up for utility and safety, and adds to the literature identifying surfactant protein D as a candidate, yet predicts that integrin subunit alpha V (ITGAV) inhibition could impair some lung function me...
Jing Chen, N. Shrine, Kayesha Coley et al.· ERJ Open Research· 0 citations
This study provides the most comprehensive assessment of IBS genetics to date, demonstrating reproducible polygenic inheritance and linking IBS risk to convergent neurogastrointestinal and novel cardiometabolic mechanisms, highlight specific biological pathways and actionable mechanisms and outline translational opport...
Biagio Di Lorenzo, L. Camargo Tavares, Cristian Díaz-Muñoz et al.· Gut· 0 citations
We use cookies to run the site and, with your consent, for analytics and to show ads.
See our Cookie Policy.