Open access
Aug 2026
Identification of a Mirror-Image VHH Antibody with VEGF-Inhibitory Activity and Characterization of Its Immunogenicity
Immunogenicity remains a major challenge in antibody therapeutics. Antibodies can be recognized as foreign by immune cells, leading to the induction of antidrug antibodies that ultimately compromise therapeutic efficacy. This response is primarily driven by proteolytic processing within antigen-presenting cells and t...
Kayuu Maeda, Manrei Yonemura, Keisuke Aoki et al.
· Bioconjugate chemistry · 0 citations