Kathryn S. E. Cheah

Opposing activity of SOX9 and Wnt in the developing otocyst ensures SOX10 control of endolymphatic development.

Proper development of the inner ear, including specification and differentiation of progenitors for the endolymphatic sac, is crucial for hearing and balance. In a mouse model of the SOX9Y440X/+ mutation that causes campomelic dysplasia and deafness, impaired development of the endolymphatic system at mid-gestation was...