Sep 2026
The RAMP3 proximity interactor MYO6 determines spatiotemporal signaling of the GPCR CLR in lymphatic endothelial cells.
Receptor activity-modifying protein 3 (RAMP3) heterodimerizes with the G protein-coupled receptor (GPCR) calcitonin receptor-like receptor (CLR) to form the receptor for the prolymphangiogenic peptide adrenomedullin (AM). RAMP3 allosterically regulates CLR to coordinate signaling, internalization, and endosomal recycli...
D. Serafin, Monserrat Avila-Zozaya, Poonam Kumari et al.
· Science Signaling · 0 citations