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Katherine J. Vietor

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Open access Oct 2026

Folate metabolism in tumor-associated macrophages drives immunosuppressive function to promote tumor growth

Tumor-associated macrophages (TAMs) promote tumor growth, inhibit effector lymphocytes, and induce resistance to immune checkpoint inhibitors (ICI). Therapies designed to deplete TAMs have had little success in the clinic, and strategies aimed to repolarize immunosuppressive TAMs to pro-inflammatory states have struggl...

Matthew P. Zimmerman, Vasyl Zhabotynsky, Hai-Yang Wang et al. · 0 citations

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