Open access
Sep 2026
Context-specific genetic interaction mapping reveals combinatorial KRAS/FGFR dependence in pancreatic cancer
Oncogenic KRAS drives >90% of pancreatic ductal adenocarcinoma (PDAC), and the pan-RAS inhibitor daraxonrasib doubles overall survival, but adaptive and acquired resistance limit the depth and duration of responses. To systematically map combination vulnerabilities, we developed RAS+, a digenic CRISPR knockout library...
R. Ebright, Yao He, Alan Zhang et al.
· bioRxiv · 0 citations