Oocytes are densely packed with mitochondria, the energy-producing organelles that contain their own genome, mitochondrial DNA (mtDNA). Each cell contains multiple copies of mtDNA, with copy number varying among tissue types. Oocytes possess the highest mtDNA copy number, containing hundreds of thousands of mtDNA molec...
Teresa Kloimboeck, Thomas Ebner, Kateryna D. Makova et al.· Journal of Visualized Experi...· 0 citations
The common marmoset is a New World monkey (NWM) commonly used as a model organism to investigate questions in primate evolution and human disease, including Alzheimer’s and other neurodegenerative diseases, as well as neuropsychiatric disorders. Here we present the first telomere-to-telomere (T2T) reference genome for...
Prajna Hebbar, Tamara A. Potapova, Hailey Loucks et al.· bioRxiv· 0 citations
This complete genome of a songbird serves as a public reference and illuminates avian genome architecture and function and suggests that birds possess a kinetochore-associated CENP system similar to that of mammals.
G. Formenti, Nivesh Jain, Jack A. Medico et al.· Cell· 2 citations
By bridging statistical phylogenetics with geometric representation learning, HyphAeon establishes comparative genomics as an interactive, high-throughput computational framework for evolutionary discovery.
Sergei L. Kosakovsky Pond, Steven Weaver, Danielle Callan et al.· bioRxiv· 0 citations
It is demonstrated that it is possible to sequence permanganate-modified DNA directly using ONT, with minimal effects on the read length, yield, and alignment accuracy, and at high ONT sequencing depth, this approach can identify B-folded vs. single-stranded DNA regions in cells, with ssDNA frequently present across se...
Jacob P. Sieg, Huiqing Zeng, Lauren Heaverly et al.· bioRxiv· 0 citations
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