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Katerina Konstantoulea

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Open access Sep 2026

An N-terminal ATTR Fibril Segment Promotes Transthyretin Amyloid Nucleation and Polymorphism

ATTR amyloidosis is caused by transthyretin (TTR) amyloid deposition, yet the sequence-encoded events linking TTR misfolding to fibril nucleation and structural polymorphism remain incompletely defined. Here, we exploit the modular organization of patient-derived TTR fibrils to investigate two components of the patholo...

Laxmikant Gadhe, B. Nguyen, María del Carmen Fernández-Ramírez et al. · 0 citations

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