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Katarzyna Lipke

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Review Open access Sep 2026

Intracellular Crosstalk Between NMDA and Sigma-1 Receptors: A Novel Mechanistic Insight Relevant to Neuropsychiatric Pharmacotherapy

Highlights What are the main findings? • The σ1R and NMDAR are functionally linked through shared intracellular signaling pathways.• Many pharmacological (e.g., ketamine, dextromethorphan) and physiological agents (neurosteroids) act through both σ1R and NMDAR mechanisms. What are the implications of the main findings?...

Katarzyna Lipke, A. Piwowar · 0 citations

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