Author

Katarzyna Kulej

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Sep 2026

Abstract B010: ELUCIDATING DNA DAMAGE REPAIR SIGNALING AND THERAPEUTIC VULNERABILITIES ACTIVATED BY TRANSPOSASE-DERIVED PGBD5

One hallmark of pediatric tumors is their low mutational burden, which contrasts with adult tumors, where cancer-causing mutations often accumulate over decades of DNA replication and environmental exposure. This raises the question of how such mutations arise in young patients. We have proposed that developmental mu...

Helen S. Mueller, Kaisha Garvin, Sophia Rha et al. · Cancer Research · 0 citations

Sep 2026

Abstract B009: DNA-proximal MYB phosphorylation is required for oncogenic transcription in acute myeloid leukemia

DNA-proximal phosphorylation of MYB is identified as a critical regulatory mechanism required for MYB oncogenesis through cooperative organization of transcription factors and nominated MYB N-terminal phosphorylation and its upstream kinases as candidate therapeutic targets for MYB-dependent leukemia.

Shu-Yuan Cheng, Katarzyna Kulej, Masahiro Uni et al. · Cancer Research · 0 citations

Open access Aug 2026

Recurrent non-canonical proteoforms in acute myeloid leukemia identified by integrative proteogenomics

Reference proteomes incompletely represent proteins translated in cancer, leaving tumor-specific proteoforms outside the search space of conventional mass spectrometry (MS). Such “dark proteome” products may arise from genomic variation, aberrant transcription or splicing, and non-canonical translation, including micro...

L. Schmalbrock, Asher Preska Steinberg, Katarzyna Kulej et al. · bioRxiv · 0 citations