Author

Kashish Chetal

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Open access Oct 2026

An epigenetic program dictates MYC amplification dynamics that promote transient, extrachromosomal, and inherited genomic events.

MYC amplification is common and often extrachromosomal (ecDNA) in cancer. To define how MYC DNA copy gains arise from diploid genomes, we assessed whether epigenetic enzymes directly control focal MYC over-replication and amplification. We demonstrate that H3K4 methylation primes MYC for amplification by the H3K9/K36 t...

Benjamin Ferman, Chloe Azadegan, John Santoro et al. · Molecules and Cells · 0 citations

Open access Aug 2026

A multi-functional oral small molecule targeting energy and lipid metabolism to treat obesity and related metabolic disorders

Obesity and related metabolic disorders have surged globally, and are mechanistically interconnected through dysregulated energy and lipid metabolism pathways. Current incretin-based obesity treatments act to decrease food intake, but are associated with gastrointestinal side effects and muscle wasting. Here, we identi...

Justin Y. Lee, Chi Zhu, Melissa A. Boldridge et al. · Science Advances · 1 citation