Kasandra Romo

Depolarization block in substantia nigra pars reticulata neurons drives dystonia in a mouse model

Dystonia is a common movement disorder characterized by involuntary co-contraction of antagonist muscles, resulting in abnormal postures. The brain often appears grossly normal, suggesting dysfunctional neural activity as a cause. The basal ganglia are implicated in dystonia, but the causal patterns of neural activity...