Toward a minimal amino acid alphabet for protein design
A bstract Proteins are built from 20 canonical amino acids. It is interesting to explore whether proteins can be formed from significantly reduced amino acid alphabets. Our bioinformatics survey of UniProt (more than 250 M sequences) revealed that proteins composed of reduced amino acid alphabets (< 10) are extremely r...
Karel Půbal, Kseniia Kushnir, Vojtěch Spiwok et al.
· FEBS Journal · 0 citations