A covalent peptide engager approach to equip immunotherapeutic monoclonal and pan IgG serum antibodies with new tumour-targeting function.
BACKGROUND AND PURPOSE Site-specific antibody modification is a useful chemical strategy to elaborate antibody therapeutic function. Conventional lysine- or cysteine-based conjugation methods generate heterogeneous products, while protein engineering approaches are resource-intensive. Affinity-guided covalent strategie...