Karla Vollmerig

Reassessing Tcf21-iCre for Adult Cardiac Fibroblast Gene Deletion: Limited Recombination Efficiency Following Tamoxifen Injections

Tcf21-iCre cannot reliably achieve broad gene deletion in adult cardiac fibroblasts with i.p. tamoxifen injection, limiting its usability in loss-of-function studies that require broad fibroblast coverage and highlighting the need for alternative Cre-drivers or delivery strategies to facilitate antifibrotic therapy dev...