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Author

K. Keat

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Open access Sep 2026

Phenome- and laboratory-wide meta-analyses of sickle cell trait reveal multi-system disease associations

Sickle cell trait (SCT) is increasingly recognized as a risk factor for adverse health outcomes. We utilized three large US electronic health record-based biobanks (Vanderbilt University Medical Center’s BioVU, Penn Medicine Biobank, and All of Us) to conduct phenome-wide association (PheWAS) and clinical laboratory-wi...

M. Hysong, Megan M. Shuey, T. Miller-Fleming et al. · 0 citations
Open access Aug 2026

A Computational and Statistical Framework Leveraging AI-Derived CT Phenotypes for Causal Mediation Effects Between Genetic Variants and Disease

As the costs of genetic sequencing continue to drop and human genomic biobanks grow in scale, the challenge in genomics has shifted increasingly towards disentangling whether and how associated genetic variants cause disease. Clinical imaging in health-system-based biobanks provides quantitative physiological measures...

K. Keat, D.-Y. Zhang, L. Caruth et al. · 0 citations
Open access Aug 2026

Longitudinal Clinical Foundation Models Augmented with Genomics for Early Detection and Risk Stratification of Inherited Cardiomyopathy

Decomposing the onset prediction task reveals that the model often misclassifies patients who were diagnosed later as positive, suggesting the patient journey embeddings encode disease state more reliably than care timing.

A. Zolensky, Colleen M. Kripke, Karl Keat et al. · 0 citations

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