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Author

Karl A. Wessendorf-Rodriguez

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2 papers indexed here

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Open access Sep 2026

Chronic type II interferon promotes tumor growth through mitochondrial RNA-induced type I interferon and prostaglandin synthesis

Interferons are pro-inflammatory cytokines that promote immune cell engagement to eliminate malignant cells. Paradoxically, chronic interferon signaling can also activate anti-inflammatory mechanisms that allow cancer cells to evade the immune system. Here, we sought to determine the cellular mechanisms underlying this...

Melissa A. Johnson, S. Varanasi, K. Mangalhara et al. · 0 citations
Open access Sep 2026

Acetyl-CoA–dependent processes are preferentially supported by local metabolite synthesis

Using cell lines in which ACLY is localized to either compartment, it is found that ACLY in either location supports fatty acid synthesis and histone acetylation, yet compartment-localized ACLY enables finer control, providing more precise regulation.

Julianna G. Supplee, Pedro Costa-Pinheiro, Karl A. Wessendorf-Rodriguez et al. · 0 citations

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