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Karim M. Saad

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Open access Oct 2026

Entresto attenuates dexamethasone-induced metabolic dysfunction-associated steatotic features in rats: role of potential SGK1/FOXO3a regulatory pathway and cardio-metabolic axis

Prolonged or high dexamethasone (DEXA) exposure can promote steatohepatitis-like liver injury through insulin resistance, oxidative stress, inflammation, mitochondrial dysfunction, and fibrosis. Sacubitril/valsartan (Entresto) exhibits metabolic, anti-inflammatory, and antifibrotic properties that may protect again...

Mutni Kh. Alreshidi, Karim M. Saad, M. Zaghloul et al. · 0 citations

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