Kang-Zhou Huang

An integrated platform for genome-wide functional analysis in Aspergillus niger through Ac/Ds insertion profiling and metabolic modeling

Genome-scale metabolic models guide rational strain engineering, while high-throughput insertional mutagenesis enables systematic investigation of gene function and condition-dependent growth requirements. However, a platform integrating high-density transposon insertion sequencing with matched stoichiometric, thermody...